Preclinical therapies to prevent or treat fracture non-union: A systematic review.

ABSTRACT:

Background

Non-union affects up to 10% of fractures and is associated with substantial morbidity. There is currently no single effective therapy for the treatment or prevention of non-union. Potential treatments are currently selected for clinical trials based on results from limited animal studies, with no attempt to compare results between therapies to determine which have the greatest potential to treat non-union.

Aim

The aim of this systematic review was to define the range of therapies under investigation at the preclinical stage for the prevention or treatment of fracture non-union. Additionally, through meta-analysis, it aimed to identify the most promising therapies for progression to clinical investigation.

Methods

MEDLINE and Embase were searched from 1St Ja

SUBMITTER: Bennett PM 

PROVIDER: S-EPMC6070249 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature