Comparative transcriptomics reveals specific responding genes associated with atherosclerosis in rabbit and mouse models.

ABSTRACT: Mouse and rabbit are frequently employed species for atherosclerosis research. With respect to modeling human atherosclerosis, it has been observed that variations in phenotype under commonly used atherogenic conditions are partial or no congruence between two species. However, genome-wide molecular variations are still lacking. To understand the differences between rabbit and mouse in developing atherosclerosis, here from aspect of orthologs, we compared the genome-wide expression profiles of two species under the same atherosclerosis driven factors: high-fat diet or LDLR deficiency. Our results illuminated that: 1) LDLR-deficiency induced different gene expression changes in rabbit and mouse. WHHL rabbit had more significantly differential expressed genes and the most of genes were down-

SUBMITTER: Wu L 

PROVIDER: S-EPMC6070260 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature