Transcriptome signature for dietary fructose-specific changes in rat renal cortex: A quantitative approach to physiological relevance.

ABSTRACT: Fructose consumption causes metabolic diseases and renal injury primarily in the renal cortex where fructose is metabolized. Analyzing gene differential expression induced by dietary manipulation is challenging. The effects may depend on the base diet and primary changes likely induce secondary or higher order changes that are difficult to capture by conventional univariate transcriptome analyses. We hypothesized that dietary fructose induces a genetic program in the kidney cortex that favors lipogenesis and gluconeogenesis. To test this, we analyzed renal cortical transcriptomes of rats on normal- and high-salt base diets supplemented with fructose. Both sets of data were analyzed using the Characteristic Direction method to yield fructose-induced gene vectors of associated differential e

SUBMITTER: Gonzalez-Vicente A 

PROVIDER: S-EPMC6070266 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature