Lateral inhibition: Two modes of non-autonomous negative autoregulation by neuralized.

ABSTRACT: Developmental patterning involves the progressive subdivision of tissue into different cell types by invoking different genetic programs. In particular, cell-cell signaling is a universally deployed means of specifying distinct cell fates in adjacent cells. For this mechanism to be effective, it is essential that an asymmetry be established in the signaling and responding capacities of the participating cells. Here we focus on the regulatory mechanisms underlying the role of the neuralized gene and its protein product in establishing and maintaining asymmetry of signaling through the Notch pathway. The context is the classical process of "lateral inhibition" within Drosophila proneural clusters, which is responsible for distinguishing the sensory organ precursor (SOP) and non-SOP fates amo

SUBMITTER: Miller SW 

PROVIDER: S-EPMC6070291 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature