Evidence of cardiac involvement in the fetal inflammatory response syndrome: disruption of gene networks programming cardiac development in nonhuman primates.

ABSTRACT:

Background

Most early preterm births are associated with intraamniotic infection and inflammation, which can lead to systemic inflammation in the fetus. The fetal inflammatory response syndrome describes elevations in the fetal interleukin-6 level, which is a marker for inflammation and fetal organ injury. An understanding of the effects of inflammation on fetal cardiac development may lead to insight into the fetal origins of adult cardiovascular disease.

Objective

The purpose of this study was to determine whether the fetal inflammatory response syndrome is associated with disruptions in gene networks that program fetal cardiac development.

Study design

We obtained fetal cardiac tissue after necropsy from a well-described pregnant nonhuman primate model (pigtail mac

SUBMITTER: Mitchell T 

PROVIDER: S-EPMC6070341 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature