Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Vega F
PROVIDER: S-EPMC6070353 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Cell 20180401 2
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathw ...[more]