Electrochemical oxidative oxysulfenylation and aminosulfenylation of alkenes with hydrogen evolution.

ABSTRACT: Difunctionalization of alkenes is a valuable and versatile chemical transformation that could quickly build complex molecules. Extensive efforts have been made, and great achievement, such as Sharpless aminohydroxylation and dihydroxylation, has been reached. However, in marked contrast to the extensive research of aminohydroxylation and dihydroxylation, directly using thiophenols/thiols and O/N-nucleophiles to perform the difunctionalization of alkenes that form the C-S and C-O/N bonds together is still underexplored. The main issue is that thiophenols/thiols are often easily overoxidized to sulfoxides or sulphones under such essential oxidation conditions. We demonstrate an electrochemical oxidative oxysulfenylation and aminosulfenylation of alkenes. A critical feature of this transforma

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC6070360 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature