Subjective cognitive decline and risk of MCI: The Mayo Clinic Study of Aging.

ABSTRACT:

Objective

We investigated different dimensions of subjective cognitive decline (SCD) to determine which was the best prognostic risk factor for incident mild cognitive impairment (MCI) among cognitively unimpaired participants.

Methods

We included 1,167 cognitively unimpaired participants, aged 70 to 95 years, from the Mayo Clinic Study of Aging based on 2 concurrent SCD scales (part of the Blessed memory test and the 39-item Everyday Cognition [ECog] scale, which included a validated 12-item derivative) and a single question assessing worry about cognitive decline. We evaluated multiple ways to dichotomize scores. In continuous models, we compared average scores on 4 ECog domains and multidomain (39- and 12-item) ECog scores. Cox proportional hazards models were used to ass

SUBMITTER: van Harten AC 

PROVIDER: S-EPMC6070384 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature