Vitamin D supplementation decreases immune activation and exhaustion in HIV-1-infected youth.

ABSTRACT:

Background

Heightened immune activation and exhaustion drive HIV disease progression and comorbidities. Vitamin D has pleiotropic immunomodulatory effects, but little is known about the effects of supplementation in HIV. Our study investigates changes in immune activation and exhaustion markers after 12 months of supplementation in virologically suppressed HIV-infected youth with vitamin D insufficiency.

Methods

This is a randomized, active-control, double-blind trial investigating with three different vitamin D₃ doses (18,000 [standard/active-control dose], 60,000 [moderate dose] and 120,000 IU/month [high dose]) in 8-25-year-old HIV-infected youth on combination antiretroviral therapy with baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations ≤30 ng/ml. On

SUBMITTER: Eckard AR 

PROVIDER: S-EPMC6070412 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature