[¹¹C]SCH23390 binding to the D₁-dopamine receptor in the human brain-a comparison of manual and automated methods for image analysis.

ABSTRACT:

Background

The D₁-dopamine receptor radioligand [¹¹C]SCH23390 has been frequently used in PET studies. In drug-naïve patients with schizophrenia, the findings have been inconsistent, with decreases, increases, and no change in the frontal cortex D₁-dopamine receptors. While these discrepancies are likely primarily due to a lack of statistical power in these studies, we speculated that an additional explanation may be the differences due to methods of image analysis between studies, affecting reliability as well as bias between groups.

Methods

Fifteen healthy subjects underwent two PET measurements with [¹¹C]SCH23390 on the same day. The binding potential (BP_ND) was compared using a 95% confidence interval following manua

SUBMITTER: Stenkrona P 

PROVIDER: S-EPMC6070454 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature