Evaluating protective and therapeutic effects of alpha-lipoic acid on cisplatin-induced ototoxicity.

ABSTRACT: Cisplatin, a small platinum-containing molecule, is a widely used, highly effective anticancer drug. However, severe side effects have been found in cancer patients treated with cisplatin, including nephrotoxicity, neurotoxicity, and ototoxicity. These cisplatin-induced side effects can have a major impact on patient quality of life, including social development problems in pediatric patients that develop hearing loss. Previous studies have suggested that the major cause of cisplatin-induced ototoxicity is abnormal accumulation of reactive oxygen species (ROS) and oxidative stress. Alpha-lipoic acid (ALA), one of the most effective antioxidants, is known to be involved in the cellular antioxidant system and may have a protective effect on cisplatin-induced ototoxicity. However, the therape

SUBMITTER: Kim KH 

PROVIDER: S-EPMC6070527 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature