Comparison of electrophysiological properties of two types of pre-sympathetic neurons intermingled in the hypothalamic paraventricular nucleus.

ABSTRACT: The hypothalamic paraventricular nucleus (PVN) contains two types of neurons projecting to either the rostral ventrolateral medulla (PVN_RVLM) or the intermediolateral horn (IML) of the spinal cord (PVN_IML). These two neuron groups are intermingled in the same subdivisions of the PVN and differentially regulate sympathetic outflow. However, electrophysiological evidence supporting such functional differences is largely lacking. Herein, we compared the electrophysiological properties of these neurons by using patch-clamp and retrograde-tracing techniques. Most neurons (＞70%) in both groups spontaneously fired in the cell-attached mode. When compared to the PVN_IML neurons, the PVN_RVLM neurons had a lower firing rate and a more irregular firing patte

SUBMITTER: Shen Y 

PROVIDER: S-EPMC6070595 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature