Quantitative Measurement of Naive T Cell Association With Dendritic Cells, FRCs, and Blood Vessels in Lymph Nodes.

ABSTRACT: T cells play a vital role in eliminating pathogenic infections. To activate, naïve T cells search lymph nodes (LNs) for dendritic cells (DCs). Positioning and movement of T cells in LNs is influenced by chemokines including CCL21 as well as multiple cell types and structures in the LNs. Previous studies have suggested that T cell positioning facilitates DC colocalization leading to T:DC interaction. Despite the influence chemical signals, cells, and structures can have on naïve T cell positioning, relatively few studies have used quantitative measures to directly compare T cell interactions with key cell types. Here, we use Pearson correlation coefficient (PCC) and normalized mutual information (NMI) to quantify the extent to which naïve T cells spatially associate with DCs, fibroblastic r

SUBMITTER: Tasnim H 

PROVIDER: S-EPMC6070610 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature