Osmotic Stress Blocks Mobility and Dynamic Regulation of Centriolar Satellites.

ABSTRACT: Centriolar satellites (CS) are small proteinaceous granules that cluster around the centrosome and serve as cargo vehicles for centrosomal proteins. It is generally accepted that CS support a number of canonical and specialized centrosome functions. Consequently, these highly dynamic structures are the target of regulation by several cellular signalling pathways. Two decades of research have led to the identification of a large number of molecular components and new biological roles of CS. Here, we summarize the latest advances in the continuous efforts to uncover the compositional, functional, dynamic and regulatory aspects of CS. We also report on our discovery that osmotic stress conditions render CS immobile and insensitive to remodelling. Upon a range of p38-activating stimuli, MK2 ph

SUBMITTER: Nielsen JC 

PROVIDER: S-EPMC6070812 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature