Differential Gene Expression Profile Induced by Valproic Acid (VPA) in Pediatric Epileptic Patients.

ABSTRACT: Epilepsy is a neuronal disease that affects up to 70 million people worldwide. The development of effective therapies to combat childhood epilepsy requires early biomarkers. Here, we performed a whole-genome microarray analysis in blood cells to identify genes differentially expressed between epileptic and epileptic valproic acid (VPA)-treated children versus normal children to obtain information about the gene expression to help us to understand genetic aspects of this disease. We found that the most significant differentially expressed genes were related to the transcriptional factor cAMP-response element binding protein (CREB) that is overexpressed in children with epilepsy compared with normal children, and 6 and 12 months of VPA treatment reversed several of these changes. Interesting

SUBMITTER: Floriano-Sanchez E 

PROVIDER: S-EPMC6070821 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature