Role of Mn2+ Doping in the Preparation of Core-Shell Structured Fe₃O₄@upconversion Nanoparticles and Their Applications in T₁/T₂-Weighted Magnetic Resonance Imaging, Upconversion Luminescent Imaging and Near-Infrared Activated Photodynamic Therapy.

ABSTRACT: Core-shell (C/S) structured upconversion coated Fe₃O₄ nanoparticles (NPs) are of great interest due to their potential as magnetic resonance imaging (MRI) and upconversion luminescent (UCL) imaging agents, as well as near-infrared activated photodynamic therapy (PDT) platforms. When C/S structured Fe₃O₄@Mn2+-doped NaYF₄:Yb/Er NPs were prepared previously, well-defined C/S-NPs could not be formed without the doping of Mn2+ during synthesis. Here, the role of Mn2+ doping on the synthesis of core-shell structured magnetic-upconversion nanoparticles (MUCNPs) is investigated in detail. Core-shell-shell nanoparticles (C/S/S-MUCNPs) with Fe₃O₄ as the core, an inert layer of Mn2+-doped NaYF₄ and an outer shell consisting of Mn2+-doped NaYF₄:Yb/Er were prepared. To further develop C/S/S-MUCNPs appl

SUBMITTER: Luo Y 

PROVIDER: S-EPMC6070927 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature