Pain-Associated Transcriptome Changes in Synovium of Knee Osteoarthritis Patients.

ABSTRACT: Joint pain causes significant morbidity in osteoarthritis (OA). The aetiology of joint pain in OA is not well understood. The synovial membrane as an innervated joint structure represents a potential source of peripheral pain in OA. Here we analyse, using a hypothesis-free next generation RNA sequencing, the differences in protein-coding and non-coding transcriptomes in knee synovial tissues from OA patients with high knee pain (n = 5) compared with OA patients with low knee pain (n = 5), as evaluated by visual analogue scale (VAS). We conduct Gene Ontology and pathway analyses on differentially expressed mRNA genes. We identify new protein-coding, long non-coding RNA and microRNA candidates that can be associated with OA joint pain. Top enriched genes in painful OA knees enc

SUBMITTER: Bratus-Neuenschwander A 

PROVIDER: S-EPMC6070955 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature