The C-Type Lectin Domain Gene Family in Aedes aegypti and Their Role in Arbovirus Infection.

ABSTRACT: Several medically important flaviviruses that are transmitted by mosquitoes have been shown to bind to the C-type lectin fold that is present in either vertebrate or invertebrate proteins. While in some cases this interaction is part of a neutralizing anti-viral immune response, many reports have implicated this as critical for successful virus entry. Despite the establishment of mosquito C-type lectin domain containing proteins (CTLDcps) as known host factors in assisting the infectious process for flaviviruses, little is known about the structural characteristics of these proteins and their relationships to each other. In this report, we describe the manual annotation and structural characterization of 52 Aedes aegypti CTLDcps. Using existing RNAseq data, we establish that these genes ca

SUBMITTER: Adelman ZN 

PROVIDER: S-EPMC6070988 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature