Oncolytic Viruses as Therapeutic Tools for Pediatric Brain Tumors.

ABSTRACT: In recent years, we have seen an important progress in our comprehension of the molecular basis of pediatric brain tumors (PBTs). However, they still represent the main cause of death by disease in children. Due to the poor prognosis of some types of PBTs and the long-term adverse effects associated with the traditional treatments, oncolytic viruses (OVs) have emerged as an interesting therapeutic option since they displayed safety and high tolerability in pre-clinical and clinical levels. In this review, we summarize the OVs evaluated in different types of PBTs, mostly in pre-clinical studies, and we discuss the possible future direction of research in this field. In this sense, one important aspect of OVs antitumoral effect is the stimulation of an immune response against the tumor which

SUBMITTER: Varela-Guruceaga M 

PROVIDER: S-EPMC6071081 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature