Intracellular Localization of Blattella germanica Densovirus (BgDV1) Capsid Proteins.

ABSTRACT: Densovirus genome replication and capsid assembly take place in the nucleus of the infected cells. However, the mechanisms underlying such processes as the delivery of virus proteins to the nucleus and the export of progeny virus from the nucleus remain elusive. It is evident that nuclear transport signals should be involved in these processes. We performed an in silico search for the putative nuclear localization signal (NLS) and nuclear export signal (NES) motifs in the capsid proteins of the Blattella germanica Densovirus 1 (BgDV1) densovirus. A high probability NLS motif was found in the common C-terminal of capsid proteins together with a NES motif in the unique N-terminal of VP2. We also performed a global search for the nuclear traffic signals in the densoviruses belonging to

SUBMITTER: Kozlov EN 

PROVIDER: S-EPMC6071259 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature