Implications of population-level immunity for the emergence of artemisinin-resistant malaria: a mathematical model.

ABSTRACT:

Background

Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong Subregion, an area of relatively low transmission, but has yet to be reported in Africa. A population-based mathematical model was used to investigate the relationship between P. falciparum prevalence, exposure-acquired immunity and time-to-emergence of artemisinin resistance. The possible implication for the emergence of resistance across Africa was assessed.

Methods

The model included human and mosquito populations, two strains of malaria ("wild-type", "mutant"), three levels of human exposure-acquired immunity (none, low, high) with two types of immunity for each level (sporozoite/liver stage immunity and blood-stage/gametocyte immunity) and drug pressure based on per-capita treatment

SUBMITTER: Scott N 

PROVIDER: S-EPMC6071336 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature