Progression of cardiovascular autonomic neuropathy and cardiovascular disease in type 2 diabetes.

ABSTRACT:

Background

To examine whether the progression rate of cardiovascular autonomic neuropathy (CAN) stage is an independent predictive factor for cardiovascular disease (CVD) in type 2 diabetes.

Methods

Standardized cardiovascular autonomic reflex tests (CARTs) using traditional Ewing method were performed at baseline. The follow-up CARTs was recommended once every two years. We estimated the primary CVD endpoint, defined as coronary artery disease and ischemic stroke. The association between the progression rate of CAN stage and CVD was examined using time-dependent Cox proportional hazard models.

Results

At baseline, 578 patients completed follow-up CARTs; the cohort comprised 329 women (56.9%) with a mean age of 58.3 ± 10.3 years and a mean diabetes duration of 10.1 ± 

SUBMITTER: Yun JS 

PROVIDER: S-EPMC6071370 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature