Low and heterogeneous prevalence of glucose-6-phosphate dehydrogenase deficiency in different settings in Ethiopia using phenotyping and genotyping approaches.

ABSTRACT:

Background

8-Aminoquinolines such as primaquine clear mature Plasmodium falciparum gametocytes that are responsible for transmission from human to mosquitoes and bring radical cure in Plasmodium vivax by clearing dormant liver stages. Deployment of primaquine is thus of relevance for malaria elimination efforts but challenged by the widespread prevalence of glucose-6-phosphate dehydrogenase deficiency (G6PDd) in endemic countries since primaquine in G6PDd individuals may lead to acute haemolysis. In this study, the prevalence of G6PDd was investigated in different settings in Ethiopia using phenotyping and genotyping approaches.

Methods

Community and school based cross-sectional surveys were conducted from October to December 2016 in four administrative regions (Gambela, Ben

SUBMITTER: Shitaye G 

PROVIDER: S-EPMC6071387 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature