Regulatory network of circRNA-miRNA-mRNA contributes to the histological classification and disease progression in gastric cancer.

ABSTRACT:

Background

Little has been known about the role of non-coding RNA regulatory network in the patterns of growth and invasiveness of gastric cancer (GC) development.

Methods

MicroRNAs (miRNAs) microarray was used to screen differential miRNA expression profiles in Ming's classification. The significant differential expressions of representative miRNAs and their interacting circular RNA (circRNA) were confirmed in GC cell line and 63 pairs of GC samples. Then, a circRNA/miRNA network was constructed by bioinformatics approaches to identify molecular pathways. Finally, we explored the clinical value of the common targets in the pathway by using receiver operating characteristic curve and survival analysis.

Results

Significantly differential expressed miRNAs were found in

SUBMITTER: Cheng J 

PROVIDER: S-EPMC6071397 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature