Homology modeling of FFA2 identifies novel agonists that potentiate insulin secretion.

ABSTRACT: Critical aspects of maintaining glucose homeostasis in the face of chronic insulin resistance and type 2 diabetes (T2D) are increased insulin secretion and adaptive expansion of beta cell mass. Nutrient and hormone sensing G protein-coupled receptors are important mediators of these properties. A growing body of evidence now suggests that the G protein-coupled receptor, free fatty acid receptor 2 (FFA2), is capable of contributing to the maintenance of glucose homeostasis by acting at the pancreatic beta cell as well as at other metabolically active tissues. We have previously demonstrated that Gα_q/11-biased agonism of FFA2 can potentiate glucose stimulated insulin secretion (GSIS) as well as promote beta cell proliferation. However, the currently available Gα_q/11-bia

SUBMITTER: Villa SR 

PROVIDER: S-EPMC6071421 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature