Excitation-Contraction Coupling Time is More Sensitive in Evaluating Cardiac Systolic Function.

ABSTRACT:

Background

Pressure overload-induced myocardial hypertrophy is a key step leading to heart failure. Previous cellular and animal studies demonstrated that deteriorated excitation-contraction coupling occurs as early as the compensated stage of hypertrophy before the global decrease in left ventricular ejection fraction (LVEF). This study was to evaluate the cardiac electromechanical coupling time in evaluating cardiac systolic function in the early stage of heart failure.

Methods

Twenty-six patients with Stage B heart failure (SBHF) and 31 healthy controls (CONs) were enrolled in this study. M-mode echocardiography was performed to measure LVEF. Tissue Doppler imaging (TDI) combined with electrocardiography (ECG) was used to measure cardiac electromechanical coupling time.

SUBMITTER: Gao J 

PROVIDER: S-EPMC6071456 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature