Noninvasive Imaging of Drug-Induced Liver Injury with ¹⁸F-DFA PET.

ABSTRACT: Drug-induced liver failure is a significant indication for a liver transplant, and unexpected liver toxicity is a major reason that otherwise effective therapies are removed from the market. Various methods exist for monitoring liver injury but are often inadequate to predict liver failure. New diagnostic tools are needed. Methods: We evaluate in a preclinical model whether ¹⁸F-2-deoxy-2-fluoroarabinose (¹⁸F-DFA), a PET radiotracer that measures the ribose salvage pathway, can be used to monitor acetaminophen-induced liver injury and failure. Mice treated with vehicle, 100, 300, or 500 mg/kg acetaminophen for 7 or 21 h were imaged with ¹⁸F-FDG and ¹⁸F-DFA PET. Hepatic radiotracer accumulation was correlated to survival and percentage of no

SUBMITTER: Salas JR 

PROVIDER: S-EPMC6071498 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature