Molecular signatures of liver dysfunction are distinct in fungal and bacterial infections in mice.

ABSTRACT: Rationale: The liver is a central organ not only for metabolism but also immune function. Life-threatening infections of both bacterial and fungal origin can affect liver function but it is yet unknown whether molecular changes differ depending on the pathogen. We aimed to determine whether the hepatic host response to bacterial and fungal infections differs in terms of hepatic metabolism and liver function. Methods: We compared murine models of infection, including bacterial peritoneal contamination and infection (PCI), intraperitoneal and systemic C. albicans infection, at 6 and 24 h post-infection, to sham controls. The molecular hepatic host response was investigated by the detection of regulatory modules based on large-scale protein-protein interaction networks an

SUBMITTER: Schaarschmidt B 

PROVIDER: S-EPMC6071540 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature