Iridium (III) complex-loaded liposomes as a drug delivery system for lung cancer through mitochondrial dysfunction.

ABSTRACT:

Background and aim

Iridium (Ir)-based complex is a potential antitumor ingredient, but its poor physicochemical properties such as hydrophobicity and low biocompatibility hamper further application. Liposome provides a potential delivery approach for improving the poor physicochemical property and reducing the side effects of antitumor drug. In this study, we aimed at incorporating Ir ([Ir(ppy)₂(BTCP)]PF₆) into liposomes to enhance the biocompatibility and sustained release of Ir for intravenous administration and to elucidate the mechanism in A549 cells.

Materials and methods

Ir-loaded PEGylated liposomes (Lipo-Ir) were formulated by thin-film dispersion and ultrasonic method. Morphology, size distribution, and zeta potential of Lipo-Ir were examined b

SUBMITTER: Liao C 

PROVIDER: S-EPMC6071621 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature