Air Toxics in Relation to Autism Diagnosis, Phenotype, and Severity in a U.S. Family-Based Study.

ABSTRACT:

Background

Previous studies have reported associations of perinatal exposure to air toxics, including some metals and volatile organic compounds, with autism spectrum disorder (ASD).

Objectives

Our goal was to further explore associations of perinatal air toxics with ASD and associated quantitative traits in high-risk multiplex families.

Methods

We included participants of a U.S. family-based study [the Autism Genetic Resource Exchange (AGRE)] who were born between 1994 and 2007 and had address information. We assessed associations between average annual concentrations at birth for each of 155 air toxics from the U.S. EPA emissions-based National-scale Air Toxics Assessment and a) ASD diagnosis (1,540 cases and 477 controls); b) a continuous measure of a

SUBMITTER: Kalkbrenner AE 

PROVIDER: S-EPMC6071802 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature