Within-Day, Between-Day, and Between-Week Variability of Urinary Concentrations of Phenol Biomarkers in Pregnant Women.

ABSTRACT:

Background

Toxicology studies have shown adverse effects of developmental exposure to industrial phenols. Evaluation in humans is challenged by potentially marked within-subject variability of phenol biomarkers in pregnant women, which is poorly characterized.

Objectives

We aimed to characterize within-day, between-day, and between-week variability of phenol urinary biomarker concentrations during pregnancy.

Methods

In eight French pregnant women, we collected all urine voids over a 1-wk period (average, 60 samples per week per woman) at three occasions (15±2, 24±2, and 32±1 gestational weeks) in 2012-2013. Aliquots of each day and of the whole week were pooled within-subject. We assayed concentrations of 10 phenols in these pools, and, for two women, in all spot (unp

SUBMITTER: Vernet C 

PROVIDER: S-EPMC6071804 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature