Automated synthesis of [⁶⁸Ga]oxine, improved preparation of ⁶⁸Ga-labeled erythrocytes for blood-pool imaging, and preclinical evaluation in rodents.

ABSTRACT: Radiolabeled erythrocytes have multiple applications in nuclear medicine, including blood pool imaging. Historically they have been labeled with SPECT radionuclides. A PET blood pool imaging agent is highly desirable as it would improve clinical applications with better image quality and resolution, higher sensitivity, and dynamic scanning capabilities. With the coming of age of modern ⁶⁸Ge/⁶⁸Ga generator systems, gallium-68 is now widely accessible. In this paper we describe an updated method for the preparation of ⁶⁸Ga-labeled erythrocytes and their preliminary use in rodent blood pool imaging. A novel automated synthesis of [⁶⁸Ga]oxine using a ⁶⁸Ga/⁶⁸Ge generator and automated synthesis module is reported. [⁶⁸G

SUBMITTER: Thompson S 

PROVIDER: S-EPMC6071839 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature