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Synthesis, antioxidant and antitumoral activities of 5'-arylchalcogeno-3-aminothymidine (ACAT) derivatives.

ABSTRACT: This article presents the preparation and in vitro biological activities of new 5'-arylchalcogeno-3-aminothymidine derivatives as antioxidants (inhibition of lipid peroxidation, scavenging of the free radical 2,2-diphenylpicrylhydrazyl and demonstration of a thiol peroxidase-like activity) as well as antitumoral agents against bladder carcinoma 5637. The chalcogeno-aminothymidines presented prominent activity in the tests for both biological properties, showing a direct relation with the chalcogenium atom.

SUBMITTER: da Rosa RM

PROVIDER: S-EPMC6071852 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Synthesis, antioxidant and antitumoral activities of 5'-arylchalcogeno-3-aminothymidine (ACAT) derivatives.

da Rosa Raquel Mello RM Piccoli Bruna Candia BC da Silva Fernanda D'Avila FD Dornelles Luciano L Rocha João B T JBT Sonego Mariana Souza MS Begnini Karine Rech KR Collares Tiago T Seixas Fabiana K FK Rodrigues Oscar E D OED

MedChemComm 20161222 2

This article presents the preparation and <i>in vitro</i> biological activities of new 5'-arylchalcogeno-3-aminothymidine derivatives as antioxidants (inhibition of lipid peroxidation, scavenging of the free radical 2,2-diphenylpicrylhydrazyl and demonstration of a thiol peroxidase-like activity) as well as antitumoral agents against bladder carcinoma 5637. The chalcogeno-aminothymidines presented prominent activity in the tests for both biological properties, showing a direct relation with the ...[more]

PMID: 30108758

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