Ontology highlight
ABSTRACT:
SUBMITTER: Bian S
PROVIDER: S-EPMC6071863 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature methods 20180723 8
Brain tumors are among the most lethal and devastating cancers. Their study is limited by genetic heterogeneity and the incompleteness of available laboratory models. Three-dimensional organoid culture models offer innovative possibilities for the modeling of human disease. Here we establish a 3D in vitro model called a neoplastic cerebral organoid (neoCOR), in which we recapitulate brain tumorigenesis by introducing oncogenic mutations in cerebral organoids via transposon- and CRISPR-Cas9-media ...[more]