Reduction-rebridging strategy for the preparation of ADPN-based antibody-drug conjugates.

ABSTRACT: The reduction-rebridging strategy is a powerful method for the preparation of stable and homogeneous antibody-drug conjugates (ADCs). In this communication, we describe the development of the arylene-dipropiolonitrile (ADPN) functional group for the rebridging of reduced disulphide bonds and its application in the preparation of potent and selective ADCs.

SUBMITTER: Koniev O 

PROVIDER: S-EPMC6071946 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature