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Reduction-rebridging strategy for the preparation of ADPN-based antibody-drug conjugates.

ABSTRACT: The reduction-rebridging strategy is a powerful method for the preparation of stable and homogeneous antibody-drug conjugates (ADCs). In this communication, we describe the development of the arylene-dipropiolonitrile (ADPN) functional group for the rebridging of reduced disulphide bonds and its application in the preparation of potent and selective ADCs.

SUBMITTER: Koniev O

PROVIDER: S-EPMC6071946 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Reduction-rebridging strategy for the preparation of ADPN-based antibody-drug conjugates.

Koniev Oleksandr O Dovgan Igor I Renoux Brigitte B Ehkirch Anthony A Eberova Jitka J Cianférani Sarah S Kolodych Sergii S Papot Sébastien S Wagner Alain A

MedChemComm 20180420 5

The reduction-rebridging strategy is a powerful method for the preparation of stable and homogeneous antibody-drug conjugates (ADCs). In this communication, we describe the development of the arylene-dipropiolonitrile (ADPN) functional group for the rebridging of reduced disulphide bonds and its application in the preparation of potent and selective ADCs. ...[more]

PMID: 30108971

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