A population genomic characterization of copy number variation in the opportunistic fungal pathogen Aspergillus fumigatus.

ABSTRACT: Aspergillus fumigatus is a potentially deadly opportunistic fungal pathogen. Molecular studies have shaped our understanding of the genes, proteins, and molecules that contribute to A. fumigatus pathogenicity, but few studies have characterized genome-wide patterns of genetic variation at the population level. Of A. fumigatus genomic studies to-date, most focus mainly on single nucleotide polymorphisms and large structural variants, while overlooking the contribution of copy number variation (CNV). CNV is a class of small structural variation defined as loci that vary in their number of copies between individuals due to duplication, gain, or deletion. CNV can influence phenotype, including fungal virulence. In the present study, we characterized the population genomic patterns of CNV in a

SUBMITTER: Zhao S 

PROVIDER: S-EPMC6072042 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature