Age-related changes in estradiol and longitudinal associations with fat mass in men.

ABSTRACT:

Context

In men, circulating 17β-estradiol originates primarily from peripheral aromatization of testosterone particularly in adipose tissue. The effect of ageing and obesity on circulating estradiol remains unclear.

Objective

Determine five-year changes in serum estradiol and the association with testosterone and fat mass in Australian men.

Design

Longitudinal cohort study. At baseline and five-year follow-up, socio-demographic and health-related data including behaviors, chronic conditions, and medication use were collected by questionnaire. Estradiol and testosterone were assayed by liquid chromatography-tandem mass spectrometry and sex hormone-binding globulin by immunochemiluminescent assay. Fat mass was assessed by dual-energy X-ray absorptiometry.

Participant

SUBMITTER: Wu A 

PROVIDER: S-EPMC6072119 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature