Antiproliferative activities of alkaloid-like compounds.

ABSTRACT: Tricyclic alkaloid-like compounds were synthesised in a few steps, via the bridging Ritter reaction. The compounds were evaluated for their antiproliferative activity against the MCF-7 and the aggressive MDA-MB-231 breast cancer cells. The anti-cancer activities of 2c were found to be selective towards the aggressive and more challenging to treat triple negative (MDA-MB-231) cell line while exhibiting no antiproliferative activities towards the MCF-7 cells at the highest concentration tested (50 μM). The IC₅₀ of compound 2c was determined to be 7.9 μM for the MDA-MB-231 cell line. Furthermore, 2c arrested cell cycle at the G₂/M phase and induced apoptosis in a dose-dependent manner. Besides in-house anti-cancer screening, compound 3

SUBMITTER: Xu X 

PROVIDER: S-EPMC6072216 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature