System analysis of teratozoospermia mRNA profile based on integrated bioinformatics tools.

ABSTRACT: mRNA has an important role in spermatogenesis and the maintenance of fertility, and may act as a potential biomarker for the clinical diagnosis of infertility. In the present study, potential biomarkers associated with teratozoospermia were screened through systemic bioinformatics analysis. Initially, genome‑wide expression profiles were downloaded from the Gene Expression Omnibus and primary analysis was conducted using R software, which included preprocessing of raw microarray data, transformation between probe ID and gene symbol and identification of differentially expressed genes. Subsequently, a functional enrichment analysis was conducted using the Database for Annotation, Visualization and Integrated Discovery to investigate the biological processes involved in the development of te

SUBMITTER: Zhang T 

PROVIDER: S-EPMC6072217 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature