Identification of differentially expressed genes associated with asthma in children based on the bioanalysis of the regulatory network.

ABSTRACT: Asthma, the most common chronic respiratory tract disease in children, is characterized by allergy, recurring airway obstruction and bronchospasm. The aim of the present study was to screen critical differentially expressed genes (DEGs) involved in asthma in children. Gene expression in different tissues was compared between asthmatic children and healthy control subjects in order to identify DEGs associated with asthma. Protein‑protein interaction (PPI) networks were constructed for the DEGs and weighted gene co‑expression network analysis methods were used to further determine the functional modules associated with DEGs in different tissue samples. In addition, the gene co‑expression network was constructed. Gene Ontology function analysis and pathway analysis were conducted to identify

SUBMITTER: Wang C 

PROVIDER: S-EPMC6072229 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature