Identification of a noncoding RNA‑mediated gene pair‑based regulatory module in Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is the most common type of neurological disorder that results from brain cell death; however, not all brain regions are simultaneously affected to the same extent. Despite single biomarkers for AD having been determined on a genome‑wide scale, the differential co‑expression in gene pairs between regions and interactions with other types of cellular molecules, particularly non‑coding (nc)RNAs, are often overlooked in studies investigating the underlying mechanisms associated with AD. In the present study, based on 1,548 samples obtained from a cohort of 90 patients with AD spanning 19 brain regions, a gene‑pair based method was established for the classification of 19 brain regions into seven different groups, including marked disparate groupings of six single regio

SUBMITTER: Yu L 

PROVIDER: S-EPMC6072230 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature