Noninvasive Brain Tumor Imaging Using Red Emissive Carbonized Polymer Dots across the Blood-Brain Barrier.

ABSTRACT: Surgical resection is recognized as a mainstay in the therapy of malignant brain tumors. In clinical practice, however, surgeons face great challenges in identifying the tumor boundaries due to the infiltrating and heterogeneous nature of neoplastic tissues. Contrast-enhanced magnetic resonance imaging (MRI) is extensively used for defining the brain tumor in clinic. Disappointingly, the commercially available (MR) contrast agents show the transient circulation lifetime and poor blood-brain barrier (BBB) permeability, which seriously hamper their abilities in tumor visualization. In this work, red fluorescent carbonized polymer dots (CPDs) were systematically investigated with respect to their BBB-penetration ability. In summary, CPDs possess long excitation/emission wavelengths, low toxic

SUBMITTER: Liu Y 

PROVIDER: S-EPMC6072250 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature