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Synthesis of benzo[d]thiazole-hydrazone analogues: molecular docking and SAR studies of potential H⁺/K⁺ ATPase inhibitors and anti-inflammatory agents.

ABSTRACT: A series of new benzo[d]thiazole-hydrazones were synthesized and characterized by analytical and spectroscopic techniques. All the compounds were screened for their in vitro inhibition of H⁺/K⁺ ATPase and anti-inflammatory effects. The results revealed that compounds 6-8, 13-15, 18-20, 22, 23 and 27-30 displayed excellent inhibitory activity against H⁺/K⁺ ATPase, and their IC₅₀ values were lower than those of the standard compound omeprazole. Compounds 2-5, 9-12, 28 and 30 exhibited better anti-inflammatory activity in comparison to the standard compound indomethacin. Studies of the structure-activity relationship (SAR) showed that electron-donating gro

SUBMITTER: Wang SM

PROVIDER: S-EPMC6072339 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Synthesis of benzo[d]thiazole-hydrazone analogues: molecular docking and SAR studies of potential H⁺/K⁺ ATPase inhibitors and anti-inflammatory agents.

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Synthesis of benzo[d]thiazole-hydrazone analogues: molecular docking and SAR studies of potential H+/K+ ATPase inhibitors and anti-inflammatory agents.

OmicsDI is part of the ELIXIR infrastructure

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Synthesis of benzo[d]thiazole-hydrazone analogues: molecular docking and SAR studies of potential H⁺/K⁺ ATPase inhibitors and anti-inflammatory agents.