A Comparison of HLA Molecular Mismatch Methods to Determine HLA Immunogenicity.

ABSTRACT:

Background

Antibody-mediated rejection is a major cause of premature graft loss in kidney transplantation. Multiple scoring systems are available to assess the HLA mismatch between donors and recipients at the molecular level; however, their correlation with the development of de novo donor-specific antibody (dnDSA) has not been compared in recipients on active immunosuppression.

Methods

HLA-DRβ1/3/4/5/DQα1β1 molecular mismatch was determined using eplet analysis, amino acid mismatch, and electrostatic mismatch for 596 renal transplant recipients and correlated with HLA-DR/DQ dnDSA development. The molecular mismatch scores were evaluated in multivariate models of posttransplant dnDSA-free survival.

Results

Eplet mismatch correlated with amino acid mismatch and electr

SUBMITTER: Wiebe C 

PROVIDER: S-EPMC6072378 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature