Synthesis and antifungal activity of novel oxazolidin-2-one-linked 1,2,3-triazole derivatives.

ABSTRACT: Novel oxazolidin-2-one-linked 1,2,3-triazole derivatives (4a-k) were synthesized by straightforward and versatile azide-enolate (3 + 2) cycloaddition. The series of compounds was screened for antifungal activity against four filamentous fungi as well as six yeast species of Candida spp. According to their efficiency and breadth of scope, they can be ordered as 4k > 4d > 4h > 4a, especially in relation to the activity displayed against Candida glabrata ATCC-34138, Trichosporon cutaneum ATCC-28592 and Mucor hiemalis ATCC-8690, i.e. compounds 4d, 4h and 4k showed excellent activity against C. glabrata (MIC 0.12, 0.25 and 0.12 μg mL^-1, respectively), better than that of itraconazole (MI

SUBMITTER: Ramirez-Villalva A 

PROVIDER: S-EPMC6072431 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature