The critical role of novel benzophenone analogs on tumor growth inhibition targeting angiogenesis and apoptosis.

ABSTRACT: In modern biology, one of the major topics of importance is progress in anti-cancer drugs with specific targets. The angiopreventive and in vitro tumor inhibition activities of novel synthetic benzophenone analogs have been investigated intensively and explored in a very systematic way. Novel benzophenone analogs (9a-d and 10a-d) substituted with methyl, chloro and fluoro groups at different positions on an identical chemical backbone and incorporating variations in the number of substituents have been synthesized in a multistep process and characterized. In this study, we further evaluate the newly synthesized compounds for their cytotoxic and anti-proliferative effects against A549, HeLa and MCF-7 cells. The potent lead compound was further assessed for anti-angiogen

SUBMITTER: Mohammed YHE 

PROVIDER: S-EPMC6072443 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature