Evaluation of intoxicating effects of liquor products on drunken mice.

ABSTRACT: Consumption of alcoholic beverages increases the risk of human health problems such as liver, heart and blood vessel diseases. In the present study, the concept of intoxicating degree (ID) is proposed as an index to demonstrate the degree of intoxicating activity for consuming liquor products. A mice model was designed for the evaluation of liquor product IDs. The intoxicating effects of liquor products were investigated by blood alcohol concentrations (BAC) and behaviour abilities of mice including righting reflex, running and forced-swim abilities. A linear regression model between comprehensive drunkenness degree (CD), calculated by integrating BAC and the behaviour abilities, and alcohol-feeding dosages (W), was established (with R² > 0.9) with a slope factor o

SUBMITTER: Wu Z 

PROVIDER: S-EPMC6072491 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature