Triazole-diindolylmethane conjugates as new antitubercular agents: synthesis, bioevaluation, and molecular docking.

ABSTRACT: We describe the synthesis of novel triazole-incorporated diindolylmethanes (DIMs) using a molecular hybridization approach. The in vitro antitubercular activity of the DIMs against Mycobacterium tuberculosis H37Ra (ATCC 25177) was tested in the active and dormant state. Among all the synthesized conjugates, the compounds 6b, 6f, 6l, 6n, 6q, 6r, and 6s displayed good antitubercular activity against both the active and dormant Mtb H37Ra strain. The compound 6l exhibited good antitubercular activity against dormant Mtb H37Ra with an IC₅₀ value of 1 μg mL^-1 and IC₉₀ (MIC) value of 3 μg mL^-1. The compounds 6b, 6l, and 6r displayed good antitubercul

SUBMITTER: Danne AB 

PROVIDER: S-EPMC6072531 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature