Dopamine D₁ Receptor-Positive Neurons in the Lateral Nucleus of the Cerebellum Contribute to Cognitive Behavior.

ABSTRACT:

Background

Studies in humans and nonhuman primates have identified a region of the dentate nucleus of the cerebellum, or the lateral cerebellar nucleus (LCN) in rodents, activated during performance of cognitive tasks involving complex spatial and sequential planning. Whether such a subdivision exists in rodents is not known. Dopamine and its receptors, which are implicated in cognitive function, are present in the cerebellar nuclei, but their function is unknown.

Methods

Using viral and genetic strategies in mice, we examined cellular phenotypes of dopamine D₁ receptor-positive (D1R+) cells in the LCN with whole-cell patch clamp recordings, messenger RNA profiling, and immunohistochemistry to examine D1R expression in mouse LCN and human dentate nucleus of the ce

SUBMITTER: Locke TM 

PROVIDER: S-EPMC6072628 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature