Volume alteration of hippocampal subfields in first-episode antipsychotic-naive schizophrenia patients before and after acute antipsychotic treatment.

ABSTRACT: The nature of hippocampal changes in schizophrenia before first treatment, and whether hippocampal subfields are affected by antipsychotic treatment are important questions for schizophrenia research. Forty-one first-episode antipsychotic-naïve acutely ill schizophrenia inpatients had MRI scans before and six weeks after antipsychotic treatment. Thirty-nine matched healthy controls were also scanned, twenty-two of which were scanned a second time six weeks later. Volumes of hippocampal subfields were measured via FreeSurfer v6.0 using a longitudinal analysis pipeline. Before treatment, schizophrenia patients had no significant changes in total hippocampal volume but exhibited significantly greater subfield volumes than controls in bilateral molecular layers of the hippocampus (ML), bilater

SUBMITTER: Li W 

PROVIDER: S-EPMC6072650 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature